If you're interested in running fan-made projects or learning how to convert your own PSP games to ISO, I can:
If you have a PlayStation Vita, you can play the official Resident Evil 4 HD Remaster via Remote Play from a PlayStation 3/4 or through unofficial homebrew ports created by the community.
Some YouTube tutorials claim to run RE4 on the PPSSPP (PSP emulator), but these are almost always either the fan demakes mentioned above or a video stream/overlay made to look like the emulator. Summary Report Official PSP Version Fan Demake (PSP ISO) PS2 ISO (Emulated) Status Never Released Unofficial Fan Project Official Release File Format Playable On PSP / PPSSPP PS2 / AetherSX2 Experience Limited, Buggy, Demake Full Original Game
Built using the dynamic 3D Quake engine (specifically modifications like Kurok), these fan projects recreate Leon S. Kennedy’s character model, the iconic opening village stage, and Ganado enemies.
If you want to play survival horror games that actually exist as native PSP ISOs, these titles offer a similar vibe:
You cannot play the full GameCube/PS2 version of Resident Evil 4 natively on a PSP. The hardware just isn’t there. However, there are three distinct ways to get Leon’s Spanish vacation onto your handheld.